Regulation of α- synuclein expression by TRIM17 and TRIM41 Parkinson’s Diseasein

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ESR1
CNRS-IGMM, Montpellier, France
Solange Desagher

TRIM17 increases α-synuclein expression by inhibiting ubiquitination/degradation of the transcription factor ZSCAN21 mediated by TRIM41.

The aim is to assess:

  1. The role of this pathway in Parkinson’s disease models;
  2. The impact of TRIM41 and ZSCAN21 mutations identified in patients;
  3. The molecular mechanisms of TRIM41 inhibition by TRIM17.
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Vacancies