Dissecting TRIM8 function in the pathogenesis of glioblastoma

Reduced E3 ubiquitin ligase activity of TRIM8 contributes to the glioma pathogenesis.
This study aims to identify TRIM8-partners and TRIM8 glioma-related functions. Transcriptomic, proteomic, and bioinformatics will be exploited to identify TRIM8- related glioma signatures, identify novel pathways that correlate with the pathophysiology of this tumour, and ultimately indicate therapeutic avenues